The main reason microeconomics does not [need microfoundations] is that it is built from pretty solid intuitions about how individuals act.
Compare and contrast:
Which is a better foundation for microeconomics?
If you replace von Mises' intuitions with the particular intuitions neoclassical economics is built from ( to the extent that they differ), then it depends on the particular question you are trying to answer. Market activity is approximated reasonably well by the rationality assumption in a variety of cases. Kahnemann and Tversky's evidence that humans are irrational is certainly strong, but in many cases trying to incorporate this reduces tractability to such an extent that it isn't worth it, or at least we don't know how to incorporate it. A good heuristic is to use rationality for long-run phenomena and when possible, use irrationality for the short run.
I posted this comment in reply to a post by David Henderson over at econlog, but first some context.
Mathew Yglesias writes:
To which a commenter replies:
I won't reproduce the whole thing, click through to the comment to see a decent summary of the Lucas Critique if you aren't aware of it already.
Henderson, over at econlog, replies:
And without further adieu, here's my respone:
ack... I should edit my comments better before posting them (notice the use of square brackets).
edit: some minor formatting