If you replace von Mises' intuitions with the particular intuitions neoclassical economics is built from ( to the extent that they differ), then it depends on the particular question you are trying to answer. Market activity is approximated reasonably well by the rationality assumption in a variety of cases. Kahnemann and Tversky's evidence that humans are irrational is certainly strong, but in many cases trying to incorporate this reduces tractability to such an extent that it isn't worth it, or at least we don't know how to incorporate it. A good heuristic is to use rationality for long-run phenomena and when possible, use irrationality for the short run.
Even more so, Gary Becker proved in 1962 that you don't need rationality for many of the basic principles of microeconomics to hold. All you need is for each person to have a maximum budget--a noncontroversial assumption if there ever was one.
Many different kinds of non-utility-maximizing behavior and maximizing behavior across nonstandard preferences (sticky actions, bounded rationality, etc) still produce the key results.
I posted this comment in reply to a post by David Henderson over at econlog, but first some context.
Mathew Yglesias writes:
To which a commenter replies:
I won't reproduce the whole thing, click through to the comment to see a decent summary of the Lucas Critique if you aren't aware of it already.
Henderson, over at econlog, replies:
And without further adieu, here's my respone:
ack... I should edit my comments better before posting them (notice the use of square brackets).
edit: some minor formatting