That's a pretty weak argument due to the mediocrity principle and the sheer scale of the universe; while we certainly don't know the values for all parts of the Drake Equation, we have a pretty good idea, at this point, that Earth-like planets are probably pretty common, and given that abiogenesis occurred very rapidly on Earth, that is weak evidence that abiogenesis isn't hard in an absolute sense.

Most likely, the Great Filter lies somewhere in the latter half of the equation - complex, multicellular life, intelligent life, civilization, or the rapid destruction thereof. But even assuming that intelligent life only occurs in one galaxy out of every thousand, which is incredibly unlikely, that would still give us many opportunities to observe galactic destruction.

It is theoretically possible that we're the only life in the Universe, but that is incredibly unlikely; most Universes in which life exists will have life exist in more than one place.