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loqi comments on Cascio in The Atlantic, more on cognitive enhancement as existential risk mitigation - Less Wrong
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But the US did bomb Japan. For each new existentially threatening tech, the first power to develop it won't be bound by MAD.
And notice that it didn't provoke a nuclear war, and the human race still exists. Nuclear weapons weren't an existential threat until multiple parties obtained them. If MAD isn't a concern in using a given weapon, it doesn't sound like much of an existential threat.