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Neoryder comments on Is it rational to take psilocybin? - Less Wrong
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But I feel like any drastic perspective change will screw me up, whether it be positive or negative. Why would someone make the choice to change their preferences (as opposed to optimize them)?
because preferences are malleable because the people who have them are. For me most moves toward rationality is a drastic perspective change. If you fear to change your preferences the slower you go anywhere great.