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gwern comments on Is it rational to take psilocybin? - Less Wrong
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I think you're being a bit too skeptical here. Yes, I usually eat peaches because I like them and they're good for my health. But I would, in fact, expect to become more rational after eating - especially if I was about to enter a supermarket to do my grocery shopping!
There is a difference between rationality (optimal decision making based on the known facts and a set of value-weightings of possible futures) and the value-weightings themselves. It strikes me that eating the peach would quite probably alter how much you would value particular possible worlds, but I find it much more difficult to believe that it would alter your ability to deal with complexity (predict the future).