thomblake comments on Controlling your inner control circuits - Less Wrong
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One example of a control group in a psychological study (can't find reference): researchers compared freudian psychoanalysis to merely sitting there and listening.
sugar has physiological effects, so you can't really assume a sugar pill is neutral with no side-effects
And when you are testing the psychological effects of urea based salts you can't really assume lithium salts are neutral with no side-effects.