This article is a deliberate meta-troll. To be successful I need your trolling cooperation. Now hear me out.
In The Strangest Thing An AI Could Tell You Eliezer talks about asognostics, who have one of their arm paralyzed, and what's most interesting are in absolute denial of this - in spite of overwhelming evidence that their arm is paralyzed they will just come with new and new rationalizations proving it's not.
Doesn't it sound like someone else we know? Yes, religious people! In spite of heaps of empirical evidence against existence of their particular flavour of the supernatural, internal inconsistency of their beliefs, and perfectly plausible alternative explanations being well known, something between 90% and 98% of humans believe in the supernatural world, and is in a state of absolute denial not too dissimilar to one of asognostics. Perhaps as many as billions of people in history have even been willing to die for their absurd beliefs.
We are mostly atheists here - we happen not to share this particular delusion. But please consider an outside view for a moment - how likely is it that unlike almost everyone else we don't have any other such delusions, for which we're in absolute denial of truth in spite of mounting heaps of evidence?
If the delusion is of the kind that all of us share it, we won't be able to find it without building an AI. We might have some of those - it's not too unlikely as we're a small and self-selected group.
What I want you to do is try to trigger absolute denial macro in your fellow rationalists! Is there anything that you consider proven beyond any possibility of doubt by both empirical evidence and pure logic, and yet saying it triggers automatic stream of rationalizations in other people? Yes, I pretty much ask you to troll, but it's a good kind of trolling, and I cannot think of any other way to find our delusions.
Admittedly, reporting on the euphoria from alcohol largely comes from anecdotal experiences from myself and my friends and family, however, the wikipedia entry on intoxication is a good starting point for answering this question. However, asking the question did prompt me to investigate.
The short answer is that alcohol intoxication often produces euphoria at about 20-99 mg/dL and that this state may continue at higher concentrations. The mechanism appears to be due to the fact that, in addition to being a central nervous system depressant, alcohol is also a seratonin inhibitor and that it interferes with seratonin binding and seratonin transporters in a manner which causes excessive stimulation in serotonergic neurons.
That said, the specifics are unclear. It seems that we don't have direct ways of checking seratonin in human or animal brains yet. That said, indirect tests, self-report, and observed euphoric effects of alcohol intoxication all contribute to the current theory on the effects of alcohol on the seratonin receptors.
Gotcha! I had asked because the absence of a known pharmacological mechanism would have suggested that the primary factor was an association effect - people drink at parties with their friends, and therefore associate intoxication with their enjoyment of the party.