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TheOtherDave comments on Absolute denial for atheists - Less Wrong
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I know a number of people who frequently become extremely sad while drunk. Back when I drank, that wasn't an uncommon condition for me as well. Also, there were a number of enjoyable activities I found myself less able to successfully engage in while drunk... sex, in particular, was significantly less satisfying that way. In general I found several other intoxicants far superior if what I wanted was to be intoxicated.
Well, that makes some amount of sense. Alcohol is a seratonin inhibitor, so it would block some of the natural rush you would expect to get from sexual activity. That, and it inhibits testosterone, which is critical for sexual activity in men.