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taw comments on The Obesity Myth - Less Wrong
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Such as fen-phen (made illegal for absolutely no reason whatsoever, very safe), ECA (semi-legal depending on where you live, I wouldn't be surprised if it got delegalized completely at some point for no reason whatsoever, very safe), amphetamines (extremely illegal, in amounts needed to fight obesity very safe).
ECA in particular has enormous amount of research behind it, freely available on pubmed.
Unless you know the right lies.