I can't think of a single conclusive piece of evidence - but thinking the earth is NOT round would require conspiracy thinking sufficient to make the "we never landed on the moon" nuts and homeopathists look rational.
Here are 3 to start:
1) Maps work in long range air and marine navigation
2) Satellite orbital information
3) Theory of gravitational "rounding" (I can't remember the correct technical name off-hand).
Remember, this was written in 1946, well before space exploration began.
This is an excerpt from an article George Orwell wrote in 1946. I will let the text speak for itself.