What I find extremely irritating is when people talk about brain modification as if it's some sort of 1) terribly dangerous thing that 2) only happens post-uploading and 3) can only be done by direct hardware (or simulated hardware) modification. The correct answer is, "none of the above".

Lists like that have a good chance of canceling out. That is, there are a bunch of ways people disagree with you because they're talking about something else.