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pdf23ds comments on When Willpower Attacks - Less Wrong
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I cannot answer to you, because research is so limited. And research is so limited, because it's non-prescription use, so nobody is really bothered (and funded) to research it, and also because all enhancement uses are unofficial, and shunned.
Another reason is that we don't really know that much about the processes of learning, and we cannot easily test that. Testing simple things like attention and short term memory is much easier, so it's done.
Testing long-term memory would probably be pretty easy, actually, using flash card programs like Supermemo. You just measure the retention of foreign vocabulary over time, and compare based on when it was first learned and whether you were sleeping regularly or not over that time, or using modafinil, or whatever. Of course, it's still much more tricky than testing short term memory.