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Douglas_Knight comments on How does an infovore manage information overload? - Less Wrong
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Newcomb's problem is widely accepted as being related to the prisoner's dilemma. If you 2-box in Newcomb's problem, you'll never cooperate in (one-shot) PD, which is generally considered to have real-world applications.
This seems strange to me. It seems that someone sufficiently altruistic or utilitarian would cooperate on a one-shot PD, since it's not a zero-sum game (except in weird hypothetical land) and that would have no bearing on what choice one might make on Newcomb's.
ETA: for some payoff matrices.