Steve_Rayhawk comments on Reason as memetic immune disorder - Less Wrong
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This also has another side. If individual or cultural selection favors those who don't try to actually do what a religion or cultural norm tells them to do, what happens next depends on which variables are held constant. If the culture is constrained to hold constant the religion or cultural norms, then the resulting selection will cause the culture to develop blind spots, and also develop an unspoken (because unspeakable) but viciously enforced meta-norm of not seeing the blind spots. But if the culture is constrained to hold opposite meta-norms constant, such as a norm of seeing the blind spots or a norm of actually doing what one's religion or cultural norms tell one do do, then the resulting selection will act against the dangerous memes instead. This would make the culture safer for truth-seeking, and make the dividends of truth-seeking easier to pursue.
(Sometimes I worry about the problem of how to extend the principle of charity to memes that cannot be safely taken literally.)
My answer is to judge them by the success of the actions they lead their practioners to do, not the falsifiable (or deliberately unfalsifiable) claims about reality they espouse.