whpearson comments on Dying Outside - Less Wrong
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I'd try to get proficient with the tools before your body degrades too much, configuring how you would want them (perhaps getting to know the internals if they are open source) while it is still easy to make the transition less painful. I'd also try and develop a very strong ability to mentally model code and do maths, rather than using pen and paper for notes or a laptop.
It might also be worth keeping an eye on neural plasiticity research, to see if there is anything that can help your brain reconfigure after lots of its motor functions become redundant.