MichaelGR comments on Dying Outside - Less Wrong

179 Post author: HalFinney 05 October 2009 02:45AM

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Comment author: MichaelGR 06 October 2009 09:52:07PM *  0 points [-]

I'm very sorry to hear that. Truly awful. All my sympathies.

What I'm curious about is: What about the motor neurons that control the muscles used by your eyes to focus and look in different places? Are they typically affected like the others?

Comment author: LauraABJ 07 October 2009 11:34:03AM 5 points [-]

Well, the facial muscles are innervated by cranial nerves, which do not run through the spinal column (the L in ALS stands for 'lateral' referring to the disintigration of the lateral portion of spinal cord), and the eye muscles in particular send input to several motor nuclei . Since the progression of ALS tends to start in the upper or lower extremities and progresses proximally, I would guess axon length might be a factor in cell survival. Also, since ALS affects both upper and lower motor neurons, I would guess the eye's redundancy of having several motor nuclei might preserve its motor capacities.