Douglas_Knight comments on Is cryonics necessary?: Writing yourself into the future - Less Wrong
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But this estimate is essential. By deciding to pursue this course of action, you in effect state that you estimate sufficient probability of it being enough to justify the additional effort. You can't say "I don't know" and act on this knowledge at the same time.
In other words, if we don't know the necessary order of magnitude, we should only bother if we can increase our output by orders of magnitude.