I'm guessing that by the word "know" you mean "acknowledge that the evidence is strongly in favor of", which doesn't necessarily entail belief, as many religious believers have demonstrated.
If that isn't what you mean, I have no clue what you're talking about
No. I mean you can swallow a sugar pill, in full knowledge of, belief in, and acknowledgment-of-evidence-for the fact that it is a sugar pill, and still improve relative to not taking a sugar pill. It's not obvious to me why psychological "sugar pills" wouldn't work the same way.
Anticipation and faith are both aspects of the human decision process, in a sense just subroutines of a larger program, but they also generate subjective experiences (qualia) that we value for their own sake. Suppose you ask a religious friend why he doesn’t give up religion, he might say something like “Having faith in God comforts me and I think it is a central part of the human experience. Intellectually I know it’s irrational, but I want to keep my faith anyway. My friends and the government will protect me from making any truly serious mistakes as a result of having too much faith (like falling into dangerous cults or refusing to give medical treatment to my children)."
Personally I've never been religious, so this is just a guess of what someone might say. But these are the kinds of thoughts I have when faced with the prospect of giving up the anticipation of future experiences (after being prompted by Dan Armak). We don't know for sure yet that anticipation is irrational, but it's hard to see how it can be patched up to work in an environment where mind copying and merging are possible, and in the mean time, we have a decision theory (UDT) that seems to work fine, but does not involve any notion of anticipation.
What would you do if true rationality requires giving up something even more fundamental to the human experience than faith? I wonder if anyone is actually willing to take this step, or is this the limit of human rationality, the end of a short journey across the space of possible minds?