This paragraph is more important:

Although the actual Genome Project's finding of 25,000 genes fits well under Yudkowsky's attempted bound, the mathematical argument failed. A computer simulation failed to bear out the bound, and the flaw appears to have been as follows: Even if one mutation creates one death, this does not mean that one death eliminates only a single mutation. Organisms bearing more deleterious mutations are more likely to lose the evolutionary competition, and so each death can eliminate more mutations than average. If mating is random and the least fit organisms are perfectly eliminated in every generation, the information supportable in the genome goes as the inverse square of the mutation rate.