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PhilGoetz comments on Rationality Quotes: October 2009 - Less Wrong
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"Thus Aristotle laid it down that a heavy object falls faster than a light one does. The important thing about this idea is not that he was wrong, but that it never occurred to Aristotle to check it." Albert Szent-Györgyi de Nagyrápolt, winner of the Nobel Prize in Physiology or Medicine.
A good point - but also note that, when Galileo argued against Artistotelian physics in his Dialogue Concerning the Two Chief World Systems, he set forth instead the idea of the inertial reference frame - but Galileo also never felt the need to perform an experiment to verify that his shipboard "experiments" would work as he predicted. Both the wrong conclusion, and the right conclusion, were arrived at via thought-experiment. And when Einstein took the next step by proposing the special theory of relativity, that too was a thought-experiment with no validation.
In fact, one can go further, because Aristotle's conclusion was presumably arrived at in the first place through observation of everyday experience (indeed, it almost seems wrong to attribute it specifically to Aristotle since it is simply the "common sense" view of most of humanity, before and since). So here we arguably have an example of a thought experiment successfully refuting an empirically-derived hypothesis.