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Eliezer_Yudkowsky comments on Frequentist Statistics are Frequently Subjective - Less Wrong
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These seem relevant:
http://www.overcomingbias.com/2007/09/false-findings.html
"Why Most Published Research Findings Are False" I don't think he gives a figure of 2/3, but he does say: "It can be proven that most claimed research findings are false."
Thanks. Since I can't find the original reference (if, indeed, it ever existed outside my imagination) these will do equally well to illustrate the point.