I read it twice, and I'd summarize it as: for a longtime OB/LW reader, the only interesting parts are the treatment of Quantum Mechanics and the Newcomb's Dilemma chapters*. Those, incidentally, are past page 100.
* I assume that the person taking the advice is like me and has not understood very much of the 'timeless decision theory' stuff that's been flying around for months, which Drescher takes seriously (he's a user here after all), and which seem to be similar to or better to what he advocates.
A monthly thread for posting rationality-related quotes you've seen recently (or had stored in your quotesfile for ages).