In term of impact, I'd say Ben Franklin beat Hitler. Rationality + energy vs. charisma + energy. Energy seems like the key unifier, shared by almost all highly successful people. Einstein was an exception to that, but I think he's uncommon. All of the above however, took major risks in life and show a survivorship bias. I think that energy is less critical for more mundane success.

Of course, energy can come in pills but those pills tend to sap one's rationality if it wasn't extremely high to begin with (and one's physical robustness). Erdos comes to mind, but also Kennedy, Nixon, Rand, and yes, Hitler. Pills in question mimic physiology, namely, excess adrenalin, so I expect highly successful people to have high adrenalin levels or rationality, but recognize that there is usually a trade-off. Where someone has both, extreme success becomes much more likely.