I suppose Avatar is a case in point - it's worth CGIfying human actors because otherwise they would be totally out of place in the SF environment which is completely CGI.
''There are a number of shots of CGI humans,'' James Cameron says. ''The shots of [Stephen Lang] in an AMP suit, for instance — those are completely CG. But there's a threshold of proximity to the camera that we didn't feel comfortable going beyond. We didn't get too close.''
I would like to propose this as a thread for people to write in their predictions for the next year and the next decade, when practical with probabilities attached. I'll probably make some in the comments.