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lsparrish comments on Case study: Melatonin - Less Wrong
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Too low of a dosage for your body's tolerance level could explain it.
Too much is just as likely. Melatonin's response curve is weird.
Is it? It seemed like a normal enough U-curve as far as I knew.
It varies drastically from person to person. The effective dose has varied by a factor of 60 even among people I've designed cognitive/nutritional stacks for and varies even more so in the general case.
The inverted U is also different to the way it is usually used. Usually things have benefits to a certain level but then disadvantages start weighing them down if the dose gets too high. The cognitive enhancement from stimulants like caffeine for example reaches a peak then declines along that specific metric. But you certainly don't go back towards normal in the obvious effects. You're totally wired. With melatonin some will get a drastic alteration in their sleep behavior at 0.5 mg while a mega dose of 100 mg is not incredibly disruptive. For a hormone and especially a hormone with mind altering effects you can't usually get away with that.
I meant more in the way of clinical evidence, than anecdotes; I've never tried 100mg or heard of trying it before (my 1 9mg experience being sufficiently unpleasant to deter me from higher doses), so I guess I have to take your word for it on the claim of it not being incredibly disruptive.
You could take my word for it that large doses are not found to be incredibly disruptive (even in the long term) in clinical studies either.