I might be wrong in my beliefs about their best interests, but that is a separate issue.
It's not a separate issue, it's the issue.
You want me to take as given the assumption that undergoing the treatment is in everyone's best interests but we're debating whether that makes it legitimate to force the treatment on people who are refusing it. Most of them are presumably refusing the treatment because they don't believe it is in their best interests. That fact should make you question your original assumption that the treatment is in everyone's best interests, or you have to bite the bullet and say that you are right, they are wrong and as a result their opinions on the matter can just be ignored.
Just out of curiosity, are you for or against the Friendly AI project? I tend to think that it might go against the expressed beforehand will of a lot of people, who would rather watch Simpsons and have sex than have their lives radically transformed by some oversized toaster.
In this video, Julian Savulescu from the Uehiro centre for Practical Ethics argues that human beings are "Unfit for the future" - that radical technological advance, liberal democracy and human nature will combine to make the 21st century the century of global catastropes, perpetrated by terrorists and psychopaths, with tools such as engineered viruses. He goes on to argue that enhanced intelligence and a reduced urge to violence and defection in large commons problems could be achieved using science, and may be a way out for humanity.
Skip to 1:30 to avoid the tedious introduction
Genetically enhance humanity or face extinction - PART 1 from Ethics of the New Biosciences on Vimeo.
Genetically enhance humanity or face extinction - PART 2 from Ethics of the New Biosciences on Vimeo.
Well, I have already said something rather like this. Perhaps this really is a good idea, more important, even, than coding a friendly AI? AI timelines where super-smart AI doesn't get invented until 2060+ would leave enough room for human intelligence enhancement to happen and have an effect. When I collected some SIAI volunteers' opinions on this, most thought that there was a very significant chance that super-smart AI will arrive sooner than that, though.
A large portion of the video consists of pointing out the very strong scientific case that our behavior is a result of the way our brains are structured, and that this means that changes in our behavior are the result of changes in the way our brains are wired.