I am inclined to doubt that nature's values are orthogonal to your own. Nature built you, and you are part of a successful culture produced by a successful species. Nature made you and your values - you can reasonably be expected to agree on a number of things.
From the perspective of the universe at large, humans are at best an interesting anomaly. Humans, plus all domesticated animals, crops, etc, compose less than 2% of the earth's biomass. The entire biomass is a few parts per billion of the earth (maybe it's important as a surface feature, but life is still outmassed by about a million times by the oceans and a thousand times by the atmosphere). The earth itself is a few parts per million of the solar system, which is one of several billion like it in the galaxy.
All of the mass in this galaxy, and all the other galaxy, quasars, and other visible collections of matter, are outmassed five to ten times by hydrogen atoms in intergalactic space.
And all that, all baryonic matter, composes a few percent of the mass-energy of the universe.
In this video, Julian Savulescu from the Uehiro centre for Practical Ethics argues that human beings are "Unfit for the future" - that radical technological advance, liberal democracy and human nature will combine to make the 21st century the century of global catastropes, perpetrated by terrorists and psychopaths, with tools such as engineered viruses. He goes on to argue that enhanced intelligence and a reduced urge to violence and defection in large commons problems could be achieved using science, and may be a way out for humanity.
Skip to 1:30 to avoid the tedious introduction
Genetically enhance humanity or face extinction - PART 1 from Ethics of the New Biosciences on Vimeo.
Genetically enhance humanity or face extinction - PART 2 from Ethics of the New Biosciences on Vimeo.
Well, I have already said something rather like this. Perhaps this really is a good idea, more important, even, than coding a friendly AI? AI timelines where super-smart AI doesn't get invented until 2060+ would leave enough room for human intelligence enhancement to happen and have an effect. When I collected some SIAI volunteers' opinions on this, most thought that there was a very significant chance that super-smart AI will arrive sooner than that, though.
A large portion of the video consists of pointing out the very strong scientific case that our behavior is a result of the way our brains are structured, and that this means that changes in our behavior are the result of changes in the way our brains are wired.