Andy_McKenzie comments on Normal Cryonics - Less Wrong
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I reject your framing. I would say that I had made a bad mistake. Errors do not a bad parent make. Or, to put it another way, suppose you woke up in the Christian Hell; would you plead that you had made the best decision on the available information? Scary what-ifs are no argument. You cannot make me reconsider a probability assignment by pointing out the bad consequences if my assessment is wrong; you can only do so by adding information. I understand that you believe you're trying to save my life, but please be aware that turning to the Dark Side to do so is not likely to impress me; if you need the power of the Dark Side, how good can your argument be, anyway?
The brain's functioning depends on electric and chemical potentials internal to the cells as well as connections between the cells. I believe that cryonics can maintain the network, but not the internal state of the nodes; consequently I assign "too low to meaningfully consider" to the probability of restoring my personality from my frozen brain. If the technology improves, I will reconsider.
Edit: I should specify that right now I have no children, lest I be misunderstood. It seems quite possible I will have some in the near future, though.
Not sure what exactly you mean by the "internal state of the nodes." If you are referring to inside the individual brain cells, then I think you're mistaken. We can already peer into the inside of neurons. Transmission electron microscopy is a powerful technology! Combine it with serial sectioning with a diamond knife and you can get quite a lot of detail in quite a large amount of tissue.
For example consider Ragsdale et al's recent study, to pick the first sstem scopus result. They looked at some sensory neurons in C. elegans, and were able to identify not just internal receptors but also which cells (sheath cells) contain abundant endoplasmic reticulum, secretory granules, and/or lipid globules.
This whole discussion comes down to what level of scale separation you might need to recapitulate the function of the brain and the specific characteristics that make you you. Going down to say the atomic level would probably be very difficult, for instance. But there's good reason to think that we won't have to go nearly that far down to reproduce human characteristics. Have you read the pdf roadmap? No reason to form beliefs w/o the relevant knowledge! :)
You are responding to a point somewhat at angles to the one I made. Yes, we can learn a lot about the internal state of brain cells using modern technology. It does not follow that such state survives long-term storage at liquid-nitrogen temperatures.
Is it the immediate effects of the freezing process that trouble you or the long-term effects of staying frozen for years / decades / centuries?