What's wrong with wireheading? Seriously. Heroin is harmful for numerous health and societal reasons, but if we solve those problems with wireheading, I don't see the problem with large portions of humanity choosing ultimate pleasure forever.

We could also make some workarounds: for instance, timed wireheading, where you wirehead for a year and then set your brain to disable wireheading for another year, or a more sophisticated Fun Theory based version of wireheading that allows for slightly more complex pleasures.