Wei_Dai comments on What big goals do we have? - Less Wrong
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I don't think I can be content, as long as I know how ignorant I am. See http://www.sl4.org/archive/0711/17013.html for example.
Also, I'm not sure why you define "big goal" the way you do. How does knowing that eventually you will, or won't, be satiated affect what you should do now?
It doesn't. Maybe the definition was too roundabout, and I should have asked what goals can serve as worthy lifetime projects.