There are so many different anti-depressants and the methods for choosing which ones are optimal basically come down to the intuition of the psychiatrist. It can take years to iterate through all the possible combinations of psychiatric medication if they keep failing to fix the neurotransmitter imbalance. I think anything short of 2 years is not long enough to conclude that a person's brain is irreparably broken. It's also a field that has a good chance of rapid development, such that a brain that seems irreparably broken today will certainly not always be unfixable.
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I explored a business in psychiatric genetic testing, and identified about 20 different mutations that could help psychiatrists make treatment decisions, but it was infeasible to bring to market right now without having millions of dollars for research, and the business case is not strong enough for me to raise millions of dollars for research. It'll hit the market within 10 years, sooner if the business case becomes stronger for me doing it or if I have the spare $20k to go out and get the relevant patent to see what doors that opens.
I expect the first consequence of widespread genetic testing for mental health is for NRIs to become much more widely prescribed as the firstline treatment for depression.
I can conceive of the following 3 main types of meaning we can pursue in life.
1. Exploring existing complexity: the natural complexity of the universe, or complexities that others created for us to explore.
2. Creating new complexity for others and ourselves to explore.
3. Hedonic pleasure: more or less direct stimulation of our pleasure centers, with wire-heading as the ultimate form.
What I'm observing in the various FAI debates is a tendency of people to shy away from wire-heading as something the FAI should do. This reluctance is generally not substantiated or clarified with anything other than "clearly, this isn't what we want". This is not, however, clear to me at all.
The utility we get from exploration and creation is an enjoyable mental process that comes with these activities. Once an FAI can rewire our brains at will, we do not need to perform actual exploration or creation to experience this enjoyment. Instead, the enjoyment we get from exploration and creation becomes just another form of pleasure that can be stimulated directly.
If you are a utilitarian, and you believe in shut-up-and-multiply, then the correct thing for the FAI to do is to use up all available resources so as to maximize the number of beings, and then induce a state of permanent and ultimate enjoyment in every one of them. This enjoyment could be of any type - it could be explorative or creative or hedonic enjoyment as we know it. The most energy efficient way to create any kind of enjoyment, however, is to stimulate the brain-equivalent directly. Therefore, the greatest utility will be achieved by wire-heading. Everything else falls short of that.
What I don't quite understand is why everyone thinks that this would be such a horrible outcome. As far as I can tell, these seem to be cached emotions that are suitable for our world, but not for the world of FAI. In our world, we truly do need to constantly explore and create, or else we will suffer the consequences of not mastering our environment. In a world where FAI exists, there is no longer a point, nor even a possibility, of mastering our environment. The FAI masters our environment for us, and there is no longer a reason to avoid hedonic pleasure. It is no longer a trap.
Since the FAI can sustain us in safety until the universe goes poof, there is no reason for everyone not to experience ultimate enjoyment in the meanwhile. In fact, I can hardly tell this apart from the concept of a Christian Heaven, which appears to be a place where Christians very much want to get.
If you don't want to be "reduced" to an eternal state of bliss, that's tough luck. The alternative would be for the FAI to create an environment for you to play in, consuming precious resources that could sustain more creatures in a permanently blissful state. But don't worry; you won't need to feel bad for long. The FAI can simply modify your preferences so you want an eternally blissful state.
Welcome to Heaven.