Alicorn comments on The Craigslist Revolution: a real-world application of torture vs. dust specks OR How I learned to stop worrying and create one billion dollars out of nothing - Less Wrong
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Some causes that might have the necessary general appeal and be improved by throwing vast amounts of money at them:
Nowhere near, I'm afraid. Bill Gates has already thrown a lot more than that at it.
Yeah, but what about a billion dollars in addition to what Bill Gates has thrown at it?
http://www.givewell.net/international/health/water
Data re the education?
Data on its ability to accumulate supporters, or data on it improving the areas in question?
Data on scalable education charities with high marginal benefits.
I don't know of specific organizations with very scalable approaches.