gregconen comments on The Craigslist Revolution: a real-world application of torture vs. dust specks OR How I learned to stop worrying and create one billion dollars out of nothing - Less Wrong
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I agree that making a lump-sum donation is a bad idea. But 200 million dollars (going by the OP's estimate) per year is still a lot of money for a charity to absorb. Givewell puts the "room for more funding" at $2.5 million (for 2010). This may (probably will) go up for later years, but it's a long way from $200 million. Stop TB Partnership is a bit larger, but still not $200M/year large.