Kevin comments on The Craigslist Revolution: a real-world application of torture vs. dust specks OR How I learned to stop worrying and create one billion dollars out of nothing - Less Wrong
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I would like to see this bundled with a Rational Charity meme. Let's be frank here: if this ends up going to the Society for Rare Diseases in Photogenic Puppies, it wasn't worth LW's time. If we can manage to get some money to things that actually matter, it was.
Trying to get something worthwhile done, as opposed to "making a billion dollars go to charity", might make the whole project fail because of that added extra inconvenience. So what?
If you wanted to boil it down to a meme, it would be "Do something effective for a change". Supposing you actually can generate a billion dollars, that's enough for ten million dollars for one hundred charities. "Ten million dollars apiece for one hundred unusual and effective charities." Like that.
As long as some amount of it goes to worthwhile charities, I think the whole thing would be worthwhile. I think we'd be hard pressed to lose control of the meme such that of a billion dollars at least 10 million didn't go to charities that we would want to support.