I realize that this risk is kinda insignficant compared to the risk of all life on Earth being wiped out... But I'm more than a little scared of the thought of animal uploads, and the possibility of people creating lifeforms that can be cheaply copied and replicated, without them needing to have any of the physical features that usually elict sympathy from people. We already have plenty of people abusing their animals today, and being able to do it perfectly undetected on your home upload isn't going to help things.

To say nothing about when it becomes easier to run human uploads. I just yesterday re-read a rather disturbing short story about the stuff you could theoretically do with body-repairing nanomachines, a person who enjoys abusing others, and a "pet substitute". Err, a two-year old human child, that is.