JamesAndrix comments on Hedging our Bets: The Case for Pursuing Whole Brain Emulation to Safeguard Humanity's Future - Less Wrong
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I agree entirely that humans are not friendly. Whole brain emulation is humanity-safe if there's never a point at which one person or small group and run much faster than the rest of humanity (including other uploads) The uploads may outpace us, but if they can keep each other in check, then uploading is not the same kind of human-values threat.
Even an upload singleton is not a total loss if the uploads have somewhat benign values. It is a crippling of the future, not an erasure.