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PhilGoetz comments on Open Thread: February 2010, part 2 - Less Wrong
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"How much will it cost?" "How long will it take?" Who the hell is supposed to be able to answer that on a basic research problem?
Anyone applying for grant money. Anyone working within either the academic research community or the industrial research community or the government research community.
Gentleman scientists working on their own time and money in their ancestral manors are still free to do basic research.