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MichaelVassar comments on The Shabbos goy - Less Wrong
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PLoS is a non-profit, and I'm certainly aware of it. If, however, for-profit academic journals charge much more than it costs to produce them, I would expect to see for-profit startups competing with them.
The "impact factor" measure is a part of this; you can't just start up a new journal and have a high impact factor.
PLoS claims to be sustainable on internally generated revenue at this point. I was just at their conference.