JackChristopher comments on Even if you have a nail, not all hammers are the same - Less Wrong

95 Post author: PhilGoetz 29 March 2010 06:09PM

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Comment author: Jack 30 March 2010 03:19:16PM 3 points [-]

Sure. "Known to be toxic" was probably too glib a way to put it, Phil should provide a cite and I shouldn't have repeated it uncritically. But even if this was just someone's hypothesis without much experimental evidence behind it: the concept of vitamin poisoning isn't a new one. There are publicized daily intake tolerable upper levels for lots of vitamins. Hypervitaminosis A, E. I don't know what kind of evidence backs these claims up but presumably people in the field are aware of this kind of thing. I'm not saying "These are the toxicity levels. This is why the meta analysis is wrong." I'm saying "People are hypothesizing vitamin toxicity at certain levels. Why the hell would you run an analysis that couldn't even in principle take that into account?"

Comment author: JackChristopher 01 April 2010 12:10:01AM *  1 point [-]

One thing is the fat soluble vitamins (A, E, D & K2-mk4) are [cofactors]. Vitamin A (retinol) toxicity directly depends on Vitamin D3 status.

Vitamin A is used short term at high dose 50,000 IU to 100,000 IU adjunctly to augment cancer therapy as part of core integrative nutraceutical programs (incl natural beta-carotene, high dose vitamin D 25(OH)D 75ng/ml, high dose fish oil (4-20g/day), glutamine, butyrate, etc)

Why is Vitamin A used together with Vitamin D? Why are they found in potent quantities together in nature (ie, fish liver, oily fish, salmon, oysters, trout, catfish, egg yolk, zooplankton, butter, pate, fish eggs/roe/caviar, breastmilk)? All the best foods in life... (breastmilk -- my kids were really into that stuff). Pasture-raised cows indeed produce butterfat brimming with a wealth of cardioprotective vitamins K2, A, D and E! I wonder why??

A synergistic effect has been observed for nearly all benefits studied. This makes absolute sense since they exist co-dependently physically located in the nucleus of our cells.

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