In the long run, as we understand more and more what human preferences are, I think there will be just a few coherent options: the choice of non-existence, the choice to wire-head or the choice to repress (what I consider to be) the salient aspects of consciousness and self-awareness.

In my imagination Less Wrong becomes really influential and spurs a powerful global movement, develops factions along these fault lines (with a fourth faction, clinging desperately to their moral nostalgia) and then self-destructs in a flame war to end all flame wars.

Maybe I'll write a story.

You can pry my self-awareness from my cold, dead neurons.