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gwern comments on Antagonizing Opioid Receptors for (Prevention of) Fun and Profit - Less Wrong
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Because of the possible liver damage, as far as I can tell. I think one can (relatively) safely self-administer as long as one sticks to low doses; the principle says the effect ought to be weaker, not gone.
Did you ever look into this more?
No; way too speculative. If someone were to show any effectiveness outside two or three chemical addictions/substance abuse, then I might read up on it again.