gwern comments on Do you have High-Functioning Asperger's Syndrome? - Less Wrong
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Well, that's what the series said in the first episode, and maybe the second too. I think he does come off as a little sociopathic, minus all the malevolent parts - schizoid doesn't seem to imply the manipulation or game-playing which all good Sherlocks engage in (whether they're named 'Sherlock' or 'House').