Many kinds of educated guesses about compatibility increase the probablity of finding the right person or the right relationship, because time is finite, and time spent dating a born-again Christian fundamentalist is time not spent dating an atheist librarian (or not studying Pearl or Jaynes ;-) ).
I've never dated a religious fundamentalist; I almost certainly never will. And I think that is the rational choice, even though it seems "limiting" in a sense. In reality, though, I don't think it is limiting at all, because time is not infinite, and dating opportunities are not fungible with respect to time. It's only limiting if you ignore the probability of successful outcomes based on what you know of yourself and other people, but what is a decision theory worth that ignores the probabilities altogether (and differing payoffs too)?
Edit: what holds regarding religious fundamentalists also holds to a lesser degree regarding various subsets of the average, neurotypical women that are the subject of this thread.
On the other hand, cargo-cult free-thinking can be, at least for me, far more obnoxious than just plain religious close-mindedness. And in that regard, an atheist librarian may well be much worse than a regular churchy girl (or guy).
Followup to: Do you have High-Functioning Asperger's Syndrome?
LW reader Madbadger uses the metaphor of a GPU and a CPU in a desktop system to think about people with Asperger's Syndrome: general intelligence is like a CPU, being universal but only mediocre at any particular task, whereas the "social coprocessor" brainware in a Neurotypical brain is like a GPU: highly specialized but great at what it does. Neurotypical people are like computers with measly Pentium IV processors, but expensive Radeon HD 4890 GPUs. A High-functioning AS person is an Intel Core i7 Extreme Edition - with on-board graphics!
This analogy also covers the spectrum view of social/empathic abilities, you can think about having a weaker social coprocessor than average if you have some of the tendencies of AS but not others. You can even think of your score on the AQ Test as being like the Tom's Hardware Rating of your Coprocessor. (Lower numbers are better!).
If you lack that powerful social coprocessor, what can you do? Well, you'll have to run your social interactions "in software", i.e. explicitly reason through the complex human social game that most people play without ever really understanding. There are several tricks that a High-functioning AS person can use in this situation: