Wei_Dai:
Do you really think that people like me, who do not think that literally everything is pointless and unworthy of effort, have just avoided applying the argument to some of our values?
As the only logical possibilities, it's either that, or you have thought about it and concluded that the argument is not applicable to some values. I don't find the reasons for this conclusion obvious, and I do see many selective applications of this argument as a common bias in practice, which is why I asked.
It seems obvious to me that some values (e.g., avoiding great pain) survive the argument by being hardwired to not respond to any arguments, while others (saving humanity so we can develop an intergalactic civilization, or being the first person in an eventually intergalactic civilization to really understand how decisions are supposed to be made) are grand enough that "larger scheme of things" just don't apply. (I'm not totally sure I'm interpreting your question correctly, so let me know if that doesn't answer it.)
Yes, that answers my question, thanks. I do have disagreements with your conclusion, but I grant that you are not committing the above mentioned fallacy outright.
In particular, my objections are that: (1) for many people, social isolation and lack of status is in fact a hardwired source of great pain (though this may not apply to you, so there is no disagreement here if you're not making claims about other people), (2) I find the future large-scale developments you speculate about highly unlikely, even assuming technology won't be the limiting factor, and finally (3) even an intergalactic civilization will matter nothing in the "larger scheme of things" assuming the eventual heat death of the universe. But each of these, except perhaps (1), would be a complex topic for a whole another discussion, so I think we can leave our disagreements rest at this point now that we've clarified them.
Followup to: Do you have High-Functioning Asperger's Syndrome?
LW reader Madbadger uses the metaphor of a GPU and a CPU in a desktop system to think about people with Asperger's Syndrome: general intelligence is like a CPU, being universal but only mediocre at any particular task, whereas the "social coprocessor" brainware in a Neurotypical brain is like a GPU: highly specialized but great at what it does. Neurotypical people are like computers with measly Pentium IV processors, but expensive Radeon HD 4890 GPUs. A High-functioning AS person is an Intel Core i7 Extreme Edition - with on-board graphics!
This analogy also covers the spectrum view of social/empathic abilities, you can think about having a weaker social coprocessor than average if you have some of the tendencies of AS but not others. You can even think of your score on the AQ Test as being like the Tom's Hardware Rating of your Coprocessor. (Lower numbers are better!).
If you lack that powerful social coprocessor, what can you do? Well, you'll have to run your social interactions "in software", i.e. explicitly reason through the complex human social game that most people play without ever really understanding. There are several tricks that a High-functioning AS person can use in this situation: