If your goal is to pick up women, then yes, absolutely 1 in 50 is a "win"
Sure... maybe for when you're starting out as a rank beginner, doing "cold approach" and "night game". But my success rate at "social circle game" was an order of magnitude better than that before I knew any PUA stuff in the first place... and in retrospect I can easily see how that success was based on me accidentally doing a lot of things that are explicitly taught to PUAs for that type of game.
Hell, even during the brief period where I went to nightclubs and danced with girls, there are times that I realize in retrospect I was getting major IOIs and would've gotten laid if I'd simply had even a single ounce of clue or game in my entire body... and at a better success rate than 1 in 50.
So, I'm not sure where you pulled the 1 in 50 number from, but in my experience it's not even remotely credible as a "success" for a PUA, if you mean that the PUA has to ask 50 to get 1 yes.
However, if you mean that a PUA can take 50 women who are attracted to him, and then chooses from them only the one or two that he finds most desirable, then I would agree that that's indeed a success from his POV. ;-)
(And I would also guess that most PUAs would agree that this is much closer to their idea of "winning", and that even a PUA of modest or average ability should be able to do much better than your original estimate, even for nightclub game.)
AAARGH! You're still totally responding to this as if we were having this discussion on a PUA forum, rather than on LW.
The 1 in 50 number was totally pulled out of my ass, a hypothetical intended to illustrate the idea that if a given technique works only 1 in X times, but that's enough to result in getting laid, your brain is likely to count that as a "win", and ignore the (X - 1) times it failed, leading you to incorrectly assume that the technique illustrates some universally applicable principle of human behavior, where none in fact exists.
Followup to: Do you have High-Functioning Asperger's Syndrome?
LW reader Madbadger uses the metaphor of a GPU and a CPU in a desktop system to think about people with Asperger's Syndrome: general intelligence is like a CPU, being universal but only mediocre at any particular task, whereas the "social coprocessor" brainware in a Neurotypical brain is like a GPU: highly specialized but great at what it does. Neurotypical people are like computers with measly Pentium IV processors, but expensive Radeon HD 4890 GPUs. A High-functioning AS person is an Intel Core i7 Extreme Edition - with on-board graphics!
This analogy also covers the spectrum view of social/empathic abilities, you can think about having a weaker social coprocessor than average if you have some of the tendencies of AS but not others. You can even think of your score on the AQ Test as being like the Tom's Hardware Rating of your Coprocessor. (Lower numbers are better!).
If you lack that powerful social coprocessor, what can you do? Well, you'll have to run your social interactions "in software", i.e. explicitly reason through the complex human social game that most people play without ever really understanding. There are several tricks that a High-functioning AS person can use in this situation: