I do not think there is much prospect for dramatic IQ elevation without producing somewhat damaged people.
Interesting. Would these people be so damaged that they would be unable to do science? Or would you be expecting super-aspergers types? (Or, to put it more rigorously, what probability would you assign to dead/severely disabled vs. super-aspergers/some other non-showstopping deleterious effect?)
I don't know but I can give you some candidates. One is torsion spasm (Idiopathic Torsion Dystonia). It will give you about a ten point IQ boost just by itself. Most of the time the only effect of the disease is vulnerability to writer's cramp, but 10% of the time it puts you in a wheelchair. So you could do science just fine.
Similarly the Ashkenazi form of Gaucher's disease is not ordinarily all that serious but it also give a hefty IQ boost. Asperger like stuff would probably also increase: many super bright people seem to be a bit not quite. Of course lots of other super-brights seem to be completely normal.
I am just babbling, I have no special insight at all...
HCH
Edit: Q&A is now closed. Thanks to everyone for participating, and thanks very much to Harpending and Cochran for their responses.
In response to Kaj's review, Henry Harpending and Gregory Cochran, the authors of the The 10,000 Year Explosion, have agreed to a Q&A session with the Less Wrong community.
If you have any questions for either Harpending or Cochran, please reply to this post with a question addressed to one or both of them. Material for questions might be derived from their blog for the book which includes stories about hunting animals in Africa with an eye towards evolutionary implications (which rose to Jennifer's attention based on Steve Sailer's prior attention).
Please do not kibitz in this Q&A... instead go to the kibitzing area to talk about the Q&A session itself. Eventually, this post will be edited to note that the process has been closed, at which time there should be no new questions.