bogus comments on Physicalism: consciousness as the last sense - Less Wrong
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A physical substrate, of course. Note that I am not using the word "brain": we don't know anything about what the substrate looks like from a materialistic point of view, except that it is somehow strongly related to the brain, and the fine-grained states and processes of the physical substrate should comprehensively explain our inner phenomenology.[1]
[1] This is a surprisingly strong condition. Fourier analysis on a waveform cannot comprehensively account for our auditory perceptions, because it doesn't account for psychoacoustics. Spectrum analysis on a source of visible light cannot explain the perception of color, since e.g. people have different cone photoreceptors, etc.