Let's say you have a genetic condition which causes you to gain much more weight (5x, 10x - the number is up to the reader) than a comparable non-affected person.

...also everything may be a problem and an opportunity. You could consider yourself lucky, if you wanted to become a body-builder. Some quirks can actually become an advantage. I would say a real solution (when available) is more robust than hiding from a problem (of wrong perception).