NancyLebovitz comments on Open Thread: June 2010 - Less Wrong
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Heh - my first instinct is to bite the bullet and apply CEV to existing humans only. I couldn't give a strong argument for that, though; I just can't immediately think of a reason to exclude non-culturally influenced humans while including culturally influenced humans.
It's hard to tell what counts as an influence and what doesn't.
It would be interesting to see what would happen if the effects of parasites could be identified and reversed. The results wouldn't necessarily all be good, though.